Enhancement by Adenine of the Inhibition of Salmonella Typhimurium by Ethionine.

Smith, Robert C. (Auburn University, Auburn. Ala.), and W. D. Salmon. Enhancement by adenine of the inhibition of Salmonella typhimurium by ethionine. J. Bacteriol. 89:1494-1498. 1965.-The inhibition by ethionine of the growth of Salmonella typhimurium was increased by adenine and several other purines. This effect was counteracted by the addition of methionine to the cultures. There was no preferential inhibition of nucleic acid or protein synthesis by adenine plus ethionine. Adenine stimulated the uptake of radioactive ethionine by the cells. Adenine may produce the effects observed by increasing the rate at which ethionine enters the cell and reaches its primary site of antibacterial action.